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SLAMF7 pathway expressed on NK cells diagram

Signaling lymphocytic activation molecule family member 7 (SLAMF7), an activating receptor expressed on natural killer (NK) cells, can stimulate innate and adaptive immunity.

  • SLAMF7 is an activating receptor expressed on virtually all NK cells and other immune cell subsets1
    • SLAMF7 is not expressed on solid tissues or hematopoietic stem cells2
  • Engagement of SLAMF7 activates NK cells, the rapid responders of the immune system and the body’s first line of defense against cancer3,4
  • NK cells directly kill target cells, yet spare normal cells5
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How does SLAMF7 activate innate and adaptive immunity?

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1. Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M. Cutting edge: activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. J Immunol. 2001;167(10):5517-5521. 2. Hsi ED, Steinle R, Balasa B, et al. CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma. Clin Cancer Res. 2008(9); 14:2775-2784. 3. Cruz-Munoz ME, Dong Z, Shi X, Zhang S, Veillette A. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 2009;10(3):297-305. 4. Cheng M, Chen Y, Xiao W, Sun R, Tian Z. NK cell-based immunotherapy for malignant diseases. Cell Mol Immunol. 2013;10(3):230-252. 5. Frohn C, Höppner M, Schlenke P, Kirchner H, Koritke P, Luhm J. Anti-myeloma activity of natural killer lymphocytes. Br J Haematol. 2002; 119(3):660-664. 6. Liu C, Lou Y, Lizée G, et al. Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross-priming and tumor regression in mice. J Clin Invest. 2008;118(3):1165-1175. 7. Mocikat R, Braumüller H, Gumy A, et al. Natural killer cells activated by MHC class ILow targets prime dendritic cells to induce protective CD8 T cell responses. Immunity. 2003;19(4):561-569. 8. Vivier E, Raulet DH, Moretta A, et al. Innate or adaptive immunity? The example of natural killer cells. Science. 2011; 331(6013):44-49.