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SLAMF7
- SLAMF7 is an activating receptor expressed on virtually all NK cells and other immune cell subsets1
- SLAMF7 is not expressed on solid tissues or hematopoietic stem cells2
- Engagement of SLAMF7 activates NK cells, the rapid responders of the immune system and the body’s first line of defense against cancer3,4
- NK cells directly kill target cells, yet spare normal cells5
- Continuous NK-cell activation through pathways like SLAMF7 may initiate the development of
long-term immunity6-8 - Ongoing research aims to understand how NK-cell activation through SLAMF7 impacts
long-term immunity
How does SLAMF7 activate innate and adaptive immunity?
See the impact of SLAMF7 and continuous NK cell activation
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REFERENCES–SLAMF7
1. Bouchon A, Cella M, Grierson HL, Cohen JI, Colonna M. Cutting edge: activation of NK