Realizing the Potential of
The immunogenicity of tumors varies across different malignancies
Current evidence supports
Immuno-Oncology (I-O) research across a broad range of tumors
Both solid tumors and hematologic malignancies can induce an immune response that regulates their initial growth. This ability is known as tumor immunogenicity and may occur at any of the key stages of presentation, infiltration, and elimination.1,2
Evidence of tumor immunogenicity across a wide range of solid tumors and hematologic malignancies provides the rationale for the breadth of I-O research across tumor types.22
*List of tumor types represents common tumor types, but is not exhaustive.
Research suggests that targeting immune pathways, alone or in combination, may help in eliminating tumor cells
Robust evidence supports that the body’s own immune system has the ability to induce an antitumor response against cancer.20 Research on this subject is actively under way, as evidence suggests that targeting immune pathways may help in eliminating tumor cells.21
PresentationTumors produce neoantigens that may be recognized by the immune system
A broad range of tumors are defined by a high rate of mutations, including melanoma and non-small cell lung cancer (NSCLC).3 These mutations create neoantigens that can be recognized by the immune system, activating an antitumor immune response.4
InfiltrationImmune cells infiltrate the tumor microenvironment
Numerous studies have demonstrated the presence of immune cells within the tumor microenvironment, indicating their capacity to identify and migrate to tumor cells.5-18
EliminationImmune cells can remove foreign threats
Studies have shown certain tumors reducing in size without any intervention, suggesting that the immune system can recognize and eliminate some tumor cells.19 Targeting the immune system may engage or enhance immune cell tumor elimination.
The immune system’s ability to detect and destroy tumor cells is the foundation of I-O research.22
Bristol-Myers Squibb continues to investigate the expanding field of I-O research, driven by the many patients with cancer who await the offer of renewed hope and the potential of a longer life.
References–Potential of I-O research
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